ESR Application form
- ESR 2: Discovery of potent modulators of ERAP/IRAP by fragment-based drug discovery or Kinetic Target guided synthesis
| Recruiting Institution: University of Lille, FR PhD institution: University of Lille, FR |
Supervisor: Prof. Rebecca Deprez-Poulain |
| Project Description An ESR position is available to work on the medicinal chemistry of ERAP inhibitors in the environment of the Drug discovery laboratory M2SV (www.deprezlab.fr), Lille, France. The M2SV is part of large world-class research institutes, the University of Lille hospital campus, the INSERM and the Institut Pasteur de Lille with access to a large array of the art core facilities, carrying out fundamental and applied research. The ESR will work in the M2SV team led by Pr R. Deprez-Poulain. Fragment-based drug-discovery (FBDD) and kinetic target guided synthesis (KTGS) are innovative strategies to discover hits and leads. To provide novel tools for basic research & drug discovery, the ESR will identify new chemical templates of ERAP inhibitors; screen a collection of fragments optimise hits by fragment linking or growing and KTGS. |
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| Essential Background: Master degree in organic chemistry or in medicinal chemistry | Desirable Background: previous experiences (internships) in industrial R&D setup and/or in drug discovery/ medicinal chemistry lab, PharmD and Knowledge of ADME, analytics (NMR, LCMS,…) are a plus. |
| Local Requirements | |
| Planned Secondments: Academic: National Center for Scientific Research Demokritos (Athens, GR) 2 months for structural studies; Industrial: to Edelris (Lyon, FR) 3 months for training on state-of-the art medicinal chemistry techniques | |
| Planned Starting Date: 1st Jul. 2021 | Application Deadline: application closed |