ESR Application form

  • ESR 7: Effect of IRAP inhibitors in antigen processing and presenting cell biology
Recruiting Institution: University of Paris, FR
PhD institution: University of Paris, FR
Supervisor: Prof. Peter van Endert
Project Description
An ESR position is available to work on fundamental aspects of antigen processing in the environment of the Necker campus in the heart of Paris, France. The Necker campus hosts two large world-class research institutes, Institut Necker Enfants Malades (INEM) and IMAGINE, with access to a large array of state of the art core facilities, carrying out fundamental and applied research in close link with the pediatric Necker hospital. The ESR will work in the INEM team led by P. van Endert interested in antigen processing, cell biology of antigen presenting cells and autoimmune diseases.
The selected candidate will study the function of the IRAP and ERAP aminopeptidases in the context of, and interaction with, other key molecular players such as MHC class I molecules, peptide transporters and chaperones in cross-presentation. This critical pathway functions in dendritic cells and some macrophage types to allow for priming of CD8 T lymphocytes to antigenic material, internalized by phagocytosis or endocytosis, derived from infectious agents and tumours. This fundamental project will involve application of state-of the-art approaches of cell biology and cellular immunology. Both cell lines, purified primary cells and mouse models will be used. The candidate will collaborate with a fellow PhD student studying the role and potential interest as therapeutic target of ERAP and IRAP in two rodent models of human autoimmune diseases.
Essential Background: Training in cell biology/immunology Desirable Background: training in biochemistry
Local Requirements
Planned Secondments: Academic to National Center for Scientific Research Demokritos (Athens, GR) 4M, to evaluate effects of IRAP ko on the immunopeptidome; Industrial 2M.
Planned Starting Date: 1st Oct. 2021 Application Deadline 31st Mai 2021


 


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