- ESR 6: Effect of ERAP1 modulation on induction of protective anti-tumour immunity
| Recruiting Institution: University of Southampton, UK PhD institution: University of Southampton, UK |
Supervisor: Prof. Edd James |
| Project Description An ESR position is available to work on translational aspects of antigen processing and presentation at the Centre for Cancer Immunology at the University of Southampton. The Centre is situated at the University Hospital Southampton within the Faculty of Medicine and hosts world-leaders in cancer immunology. The site offers access to state of the art facilities to enable an environment covering fundamental discovery science through to the clinic. The ESR will work in the team of E. James interested in understanding the antigen processing pathway and how this impacts on the immune response to cancer and autoimmunity. The selected candidate will study how modulation of antigen processing and presentation alters the generation and presentation of tumour antigenic peptide epitopes. This project will use advanced techniques and approaches recently developed in the lab to characterise/monitor the effect of modulation on these responses in vivo and in vitro, and may also involve genetic engineering of mouse strains. The candidate will collaborate with a fellow PhD student studying the effect of modulation of the antigen processing and presentation pathway on generation of antigenic peptide epitopes. |
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| Essential Background: Training and knowledge in immunology. Experience of immune based approaches. | Desirable Background: Experience in performing flow cytometry and T cell activation assays. Knowledge of preclinical tumour models. |
| Local Requirements: For more information and to apply please see link and emaileddjames@soton.ac.uk using the subject CAPSTONE enquiry/application. | |
| Planned Secondments: Academic to Ospedale Pediatrico Bambino Gesù (Roma, IT) 2M, to learn techniques to study effect of ERAP1 modulators ex vivo; Industrial secondment for 4 months 4M, for generation of mouse transgenes carrying human ERAP alleles. | |
| Planned Starting Date: 1st Oct. 2021 |
Application Deadline : 2nd Apr. 2021 |