ESR12: Aroosha Raja
Molecular ecosystem of ERAP four distinct immune cell subsets from patients with ERAP-linked diseases
- Scientific Background
I have completed my Masters of Science in Bioinformatics degree from COMSATS University Islamabad, Pakistan. Additionally, I also have a Bachelors of Science in Bioinformatics degree from COMSATS University Islamabad, Pakistan. Iâm a huge science enthusiast and this is the reason that both during my undergraduate and Mastersâ studies, I have been engaged in several research projects, reviewed and written different research manuscripts and thesis in the domain of Cancer genomics and Bioinformatics. During the tenure of my studies, Iâve achieved several certificates both for academic excellence and extra-curricular activities. Particularly, in research domain, Iâve undertaken different internships, part in funded projects, publications and also won travel grant for the abstract of one of my manuscripts. Apart from academic sphere, Iâm a naturalist and also love to watch and play football (huge Arsenal fan), boxing, and cricket.
- CAPSTONE project
Little is known about their transcriptional regulation of ERAPs in immune cells. The ESR will investigate ERAP regulation using bioinformatic and computational data science approaches to reconstruct the transcriptional ERAP ecosystems (i.e. regulator-target analysis and co-expression network analysis) in inflammatory conditions and publicly available data of immune cell subsets to generate testable hypotheses on molecular mechanisms involved in the regulation of ERAPs. These hypotheses will be tested in silico across the available cohort datasets and experimentally in vitro using patient materials and CRISPR-Cas9 based gene editing methods. The presence of modulators of ERAP1 and ERAP2 are explored to predict the impact of therapeutic interference of ERAP in a cell-specific manner and optimize ERAP-targeted therapy for autoimmunity.
- Supervisory team