CAPSTONE (Controlling Antigen Processing in Autoimmune diseases and Cancer) PhD project is a multi-disciplinary platform of experts in structural biology, immunology, biochemistry, proteomics, and therapeutics that jointly aim to increase the impact of research into ERAP aminopeptidases in various aspects of human and animal disease.

The CAPSTONE wishes to:

  •  Train the next generation of researchers for interdisciplinary and intersectorial careers in basic and applied medicinal chemistry, immunomodulation and pharmacology research with full understanding of the requirements of academia, pharmaceutical companies and societal challenges.
  • Elucidate through a collaborative research program, how ERAPs modulation is underlying antigen processing/presentation dysfunctions in cancer and autoimmune diseases, more specifically Spondylarthritis, and rare diseases like Birdshot chorioretinopathy.
  • Validate ERAPs as targets and bring lead modulators all the way from early stage to pre-clinical investigation in diseases of urgent medical need.
  • Form a sustainable network of excellence and ESRs that will last beyond the CAPSTONE timeline
  • Build a high-impact structure ensuring multi-level dissemination and exploitation of all results.

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 954992